vbc score Search Results


vbc scores  (Addgene inc)
90
Addgene inc vbc scores
Assessment <t>of</t> <t>Addgene</t> pooled CRISPR-spCas9 libraries for human and mouse. A Library guides were re-annotated with Exorcise using genome assembly GRCh38 (human) or GRCm38 (mouse). Re-annotations were compared with original annotations to identify off-target effects, missed-target effects, and boundary effects. B Mis-annotations identified by Exorcise. Other-locus off-target effects are caused by multiple targeting of guides to multiple loci. Same-locus off-target effects are caused by multiple knockouts by a guide due to overlapping features at a single locus. False non-targeting effects are missing annotations of a valid guide target. Missed-target effects are caused by a library guide being mis-annotated as targeting. Boundary effects are caused by mis-annotations with adjacent exons or genes. C Performance of Addgene libraries. Library guides were analysed with Exorcise with RefSeq exons. Bars indicate the proportion of guides which have any off-target effects (peach), any missed-target effects (cyan), or only on-targets (green). D Distribution of <t>VBC</t> scores among Addgene libraries. Dashed line indicates the median VBC score across all guides in all libraries. E Off-target effects of library guides in Addgene libraries. Distribution of number of off-target effects per guide by library. Inset: distribution of other-locus and same-locus off-target effects by library. F Missed-target effects in Addgene libraries. Distance between Cas9 cut site, if any, and the nearest exon in linear distance in nucleotides. Inset: zoom plot between 0 and 50 nucleotides
Vbc Scores, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/vbc scores/product/Addgene inc
Average 90 stars, based on 1 article reviews
vbc scores - by Bioz Stars, 2026-02
90/100 stars
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vbc score  (Addgene inc)
93
Addgene inc vbc score
Assessment <t>of</t> <t>Addgene</t> pooled CRISPR-spCas9 libraries for human and mouse. A Library guides were re-annotated with Exorcise using genome assembly GRCh38 (human) or GRCm38 (mouse). Re-annotations were compared with original annotations to identify off-target effects, missed-target effects, and boundary effects. B Mis-annotations identified by Exorcise. Other-locus off-target effects are caused by multiple targeting of guides to multiple loci. Same-locus off-target effects are caused by multiple knockouts by a guide due to overlapping features at a single locus. False non-targeting effects are missing annotations of a valid guide target. Missed-target effects are caused by a library guide being mis-annotated as targeting. Boundary effects are caused by mis-annotations with adjacent exons or genes. C Performance of Addgene libraries. Library guides were analysed with Exorcise with RefSeq exons. Bars indicate the proportion of guides which have any off-target effects (peach), any missed-target effects (cyan), or only on-targets (green). D Distribution of <t>VBC</t> scores among Addgene libraries. Dashed line indicates the median VBC score across all guides in all libraries. E Off-target effects of library guides in Addgene libraries. Distribution of number of off-target effects per guide by library. Inset: distribution of other-locus and same-locus off-target effects by library. F Missed-target effects in Addgene libraries. Distance between Cas9 cut site, if any, and the nearest exon in linear distance in nucleotides. Inset: zoom plot between 0 and 50 nucleotides
Vbc Score, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/vbc score/product/Addgene inc
Average 93 stars, based on 1 article reviews
vbc score - by Bioz Stars, 2026-02
93/100 stars
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crispr design tools  (Benchling Inc)
90
Benchling Inc crispr design tools
Assessment <t>of</t> <t>Addgene</t> pooled CRISPR-spCas9 libraries for human and mouse. A Library guides were re-annotated with Exorcise using genome assembly GRCh38 (human) or GRCm38 (mouse). Re-annotations were compared with original annotations to identify off-target effects, missed-target effects, and boundary effects. B Mis-annotations identified by Exorcise. Other-locus off-target effects are caused by multiple targeting of guides to multiple loci. Same-locus off-target effects are caused by multiple knockouts by a guide due to overlapping features at a single locus. False non-targeting effects are missing annotations of a valid guide target. Missed-target effects are caused by a library guide being mis-annotated as targeting. Boundary effects are caused by mis-annotations with adjacent exons or genes. C Performance of Addgene libraries. Library guides were analysed with Exorcise with RefSeq exons. Bars indicate the proportion of guides which have any off-target effects (peach), any missed-target effects (cyan), or only on-targets (green). D Distribution of <t>VBC</t> scores among Addgene libraries. Dashed line indicates the median VBC score across all guides in all libraries. E Off-target effects of library guides in Addgene libraries. Distribution of number of off-target effects per guide by library. Inset: distribution of other-locus and same-locus off-target effects by library. F Missed-target effects in Addgene libraries. Distance between Cas9 cut site, if any, and the nearest exon in linear distance in nucleotides. Inset: zoom plot between 0 and 50 nucleotides
Crispr Design Tools, supplied by Benchling Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/crispr design tools/product/Benchling Inc
Average 90 stars, based on 1 article reviews
crispr design tools - by Bioz Stars, 2026-02
90/100 stars
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vienna bioactivity crispr score  (Broad Institute Inc)
90
Broad Institute Inc vienna bioactivity crispr score
Assessment <t>of</t> <t>Addgene</t> pooled CRISPR-spCas9 libraries for human and mouse. A Library guides were re-annotated with Exorcise using genome assembly GRCh38 (human) or GRCm38 (mouse). Re-annotations were compared with original annotations to identify off-target effects, missed-target effects, and boundary effects. B Mis-annotations identified by Exorcise. Other-locus off-target effects are caused by multiple targeting of guides to multiple loci. Same-locus off-target effects are caused by multiple knockouts by a guide due to overlapping features at a single locus. False non-targeting effects are missing annotations of a valid guide target. Missed-target effects are caused by a library guide being mis-annotated as targeting. Boundary effects are caused by mis-annotations with adjacent exons or genes. C Performance of Addgene libraries. Library guides were analysed with Exorcise with RefSeq exons. Bars indicate the proportion of guides which have any off-target effects (peach), any missed-target effects (cyan), or only on-targets (green). D Distribution of <t>VBC</t> scores among Addgene libraries. Dashed line indicates the median VBC score across all guides in all libraries. E Off-target effects of library guides in Addgene libraries. Distribution of number of off-target effects per guide by library. Inset: distribution of other-locus and same-locus off-target effects by library. F Missed-target effects in Addgene libraries. Distance between Cas9 cut site, if any, and the nearest exon in linear distance in nucleotides. Inset: zoom plot between 0 and 50 nucleotides
Vienna Bioactivity Crispr Score, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/vienna bioactivity crispr score/product/Broad Institute Inc
Average 90 stars, based on 1 article reviews
vienna bioactivity crispr score - by Bioz Stars, 2026-02
90/100 stars
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vienna bioactivity crispr score portal50  (Addgene inc)
96
Addgene inc vienna bioactivity crispr score portal50
Assessment <t>of</t> <t>Addgene</t> pooled CRISPR-spCas9 libraries for human and mouse. A Library guides were re-annotated with Exorcise using genome assembly GRCh38 (human) or GRCm38 (mouse). Re-annotations were compared with original annotations to identify off-target effects, missed-target effects, and boundary effects. B Mis-annotations identified by Exorcise. Other-locus off-target effects are caused by multiple targeting of guides to multiple loci. Same-locus off-target effects are caused by multiple knockouts by a guide due to overlapping features at a single locus. False non-targeting effects are missing annotations of a valid guide target. Missed-target effects are caused by a library guide being mis-annotated as targeting. Boundary effects are caused by mis-annotations with adjacent exons or genes. C Performance of Addgene libraries. Library guides were analysed with Exorcise with RefSeq exons. Bars indicate the proportion of guides which have any off-target effects (peach), any missed-target effects (cyan), or only on-targets (green). D Distribution of <t>VBC</t> scores among Addgene libraries. Dashed line indicates the median VBC score across all guides in all libraries. E Off-target effects of library guides in Addgene libraries. Distribution of number of off-target effects per guide by library. Inset: distribution of other-locus and same-locus off-target effects by library. F Missed-target effects in Addgene libraries. Distance between Cas9 cut site, if any, and the nearest exon in linear distance in nucleotides. Inset: zoom plot between 0 and 50 nucleotides
Vienna Bioactivity Crispr Score Portal50, supplied by Addgene inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/vienna bioactivity crispr score portal50/product/Addgene inc
Average 96 stars, based on 1 article reviews
vienna bioactivity crispr score portal50 - by Bioz Stars, 2026-02
96/100 stars
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crispick tool  (Broad Institute Inc)
90
Broad Institute Inc crispick tool
Assessment <t>of</t> <t>Addgene</t> pooled CRISPR-spCas9 libraries for human and mouse. A Library guides were re-annotated with Exorcise using genome assembly GRCh38 (human) or GRCm38 (mouse). Re-annotations were compared with original annotations to identify off-target effects, missed-target effects, and boundary effects. B Mis-annotations identified by Exorcise. Other-locus off-target effects are caused by multiple targeting of guides to multiple loci. Same-locus off-target effects are caused by multiple knockouts by a guide due to overlapping features at a single locus. False non-targeting effects are missing annotations of a valid guide target. Missed-target effects are caused by a library guide being mis-annotated as targeting. Boundary effects are caused by mis-annotations with adjacent exons or genes. C Performance of Addgene libraries. Library guides were analysed with Exorcise with RefSeq exons. Bars indicate the proportion of guides which have any off-target effects (peach), any missed-target effects (cyan), or only on-targets (green). D Distribution of <t>VBC</t> scores among Addgene libraries. Dashed line indicates the median VBC score across all guides in all libraries. E Off-target effects of library guides in Addgene libraries. Distribution of number of off-target effects per guide by library. Inset: distribution of other-locus and same-locus off-target effects by library. F Missed-target effects in Addgene libraries. Distance between Cas9 cut site, if any, and the nearest exon in linear distance in nucleotides. Inset: zoom plot between 0 and 50 nucleotides
Crispick Tool, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/crispick tool/product/Broad Institute Inc
Average 90 stars, based on 1 article reviews
crispick tool - by Bioz Stars, 2026-02
90/100 stars
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Image Search Results


Assessment of Addgene pooled CRISPR-spCas9 libraries for human and mouse. A Library guides were re-annotated with Exorcise using genome assembly GRCh38 (human) or GRCm38 (mouse). Re-annotations were compared with original annotations to identify off-target effects, missed-target effects, and boundary effects. B Mis-annotations identified by Exorcise. Other-locus off-target effects are caused by multiple targeting of guides to multiple loci. Same-locus off-target effects are caused by multiple knockouts by a guide due to overlapping features at a single locus. False non-targeting effects are missing annotations of a valid guide target. Missed-target effects are caused by a library guide being mis-annotated as targeting. Boundary effects are caused by mis-annotations with adjacent exons or genes. C Performance of Addgene libraries. Library guides were analysed with Exorcise with RefSeq exons. Bars indicate the proportion of guides which have any off-target effects (peach), any missed-target effects (cyan), or only on-targets (green). D Distribution of VBC scores among Addgene libraries. Dashed line indicates the median VBC score across all guides in all libraries. E Off-target effects of library guides in Addgene libraries. Distribution of number of off-target effects per guide by library. Inset: distribution of other-locus and same-locus off-target effects by library. F Missed-target effects in Addgene libraries. Distance between Cas9 cut site, if any, and the nearest exon in linear distance in nucleotides. Inset: zoom plot between 0 and 50 nucleotides

Journal: Genome Medicine

Article Title: Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

doi: 10.1186/s13073-024-01414-4

Figure Lengend Snippet: Assessment of Addgene pooled CRISPR-spCas9 libraries for human and mouse. A Library guides were re-annotated with Exorcise using genome assembly GRCh38 (human) or GRCm38 (mouse). Re-annotations were compared with original annotations to identify off-target effects, missed-target effects, and boundary effects. B Mis-annotations identified by Exorcise. Other-locus off-target effects are caused by multiple targeting of guides to multiple loci. Same-locus off-target effects are caused by multiple knockouts by a guide due to overlapping features at a single locus. False non-targeting effects are missing annotations of a valid guide target. Missed-target effects are caused by a library guide being mis-annotated as targeting. Boundary effects are caused by mis-annotations with adjacent exons or genes. C Performance of Addgene libraries. Library guides were analysed with Exorcise with RefSeq exons. Bars indicate the proportion of guides which have any off-target effects (peach), any missed-target effects (cyan), or only on-targets (green). D Distribution of VBC scores among Addgene libraries. Dashed line indicates the median VBC score across all guides in all libraries. E Off-target effects of library guides in Addgene libraries. Distribution of number of off-target effects per guide by library. Inset: distribution of other-locus and same-locus off-target effects by library. F Missed-target effects in Addgene libraries. Distance between Cas9 cut site, if any, and the nearest exon in linear distance in nucleotides. Inset: zoom plot between 0 and 50 nucleotides

Article Snippet: D Distribution of VBC scores among Addgene libraries.

Techniques: CRISPR